Triazole Fungicide Prosaro EC 250 - induced Hematologicaland Biochemical Alterations in Male Rabbits (Oryctolagus Cuniculus)

Abstract

The study aimed to evaluate the toxic effects of fungicide Prosaro 250 EC on hematological profiles and renal functional-biochemical markers, as well as blood glucose level .Twenty-four male rabbits were equally and randomly divided into control untreated group (G1) (n =6) received distilled water and standard food, and three treated groups (n=6 each) received by oral gavage Prosaro 250 EC at three doses (mg/kg body weight (bw)), 0.093 (G2), 0.186 (G3) and 0.465 mg/kg bw (G4) for 21 days .Results revealed a significant decrease in the kidney weight, and a significant increase in the levels of serum urea, uric acid, creatinine, and glucose in Prosaro treated groups compared with the control group. Moreover, Prosaro-induced hematotoxicity was evidenced by a marked decline inred blood cell counts (RBC), hemoglobin (HGH) and hematocrit (HT) levels, along with a significant increase in white blood cell (WBC) and platelet count. Thus the sub-chronic toxicity of Prosaro 250 EC is proved to induce hematological and biochemical alterations in rabbits